ABSTRACT
During the period of prevailing unsettled COVID pandemic, the countries and states started to plan reopening during which necessitates the non-contact temperature evaluation gadgets as a part of a preliminary look at access points to identify the humans with elevated body temperatures. Despite the utilization of these devices, temperature assessment restricted the impact on lowering the spread of COVID-19. Non-contact temperature measuring devices are used to measure the temperature of any person. Detection of a high temperature is one huge manner to pick out a person who might also have COVID-19 contamination. In this project, a room environment is created in which certain precautions are taken. A laser diode and receiver are used to detect the entrance of a person, and the system also detects the body temperature of the entering person. If the temperature is less than a threshold temperature entry for the person is permitted or else the entry is denied. This system also has a feature where it permits only a pre-determined number of persons inside the room. It also facilities to view the allowed temperature, the number of people to be allowed in the room and the number of people present actively using a Bluetooth App. This system aimed to be useful to combat the spread of COVID infections. © 2022 IEEE.
ABSTRACT
The object of the analytical work is to develop an analytical multivariate optimization for the determination of Favipiravir (FAV), a SARS-CoV-2 molecule, by the reverse-phase liquid chromatographic method using the analytical quality by design approach. FAV is used as an antiviral drug. Box-Behnken design is utilized for the optimization of the experiment and to identify the critical method parameters like the volume of acetonitrile, temperature and flow rate. Further, these factors are used to design the suitable mathematical models and illustrate their effect on various responses. This newly developed method utilized C18 column (5µm, 100 × 4.6 mm) and a temperature of 40°C with a flow rate of 0.5 mL/min. The mobile phase is composed of acetonitrile and ammonium acetate buffer (pH 4), in the ratio of 20:80v/v and the wavelength of HPLC UV-Detector was fixed to 323nm. This method is validated according to International Council for Harmonization Q2 (R1) guidelines. The System suitability is performed and the retention time of Favipiravir is 3.4min. The linearity range is obtained at 0.062 - 4 µg/mL with a correlation coefficient (r2 = 0.9979). The recovery is found to be in the range of 98.84-100%. Thus, the intended method is found to be simple and robust.